As the hub of power collection, transmission and communication maintenance, the booster station plays a vital role in the offshore wind farm. In the process of loading and towing construction of offshore substation, the deformation and stress of the structure have a great influence on the safety and stability of construction. In this paper, the jacket foundation of an offshore substation is taken as the research object, and the numerical simulation method is used to study the safety and stability of the foundation loading and towing construction. Under the premise of ensuring that the jacket deformation and bar stress meet the requirements of safety specifications, the jacket stability and economic benefits of different construction schemes are compared. The results show that the jacket foundation in the form of vertical loading and towing has less deformation than the horizontal loading and towing members, and the UC stress values of the structure are reduced by 0.022 and 0.081 respectively. The members are safer during the construction process, and the requirements for the construction ship are low and the economy is better. It can provide necessary guidance for the construction of jacket foundation of offshore substation.