Based on a certain offshore wind power project, a model of the offshore booster station embedded in rock including jacket-steel tube pile-foundation was established using ABAQUS software. According to the simulated wind, wave, and current environmental loads, the influence of the elastic modulus of the foundation on the natural frequency of the structure was analyzed numerically, and the influence of the elastic modulus of the foundation and the rock-socketed depth of the steel tube pile in the moderately weathered rock stratum on the dynamic response of the structure was analyzed. The results show that the elastic modulus of the foundation is positively correlated with the natural frequency of the structure and negatively correlated with the maximum horizontal displacement at the top of the steel tube pile. With the increase in the rock-socketed depth in the moderately weathered rock stratum, the maximum horizontal displacement at the top of the steel tube pile gradually decreases, while the change in the rock-socketed depth in the moderately weathered rock stratum has little effect on the distribution of shear force and bending moment of the steel tube pile. When arranging the internal segmented grouting of the steel tube pile, it is necessary to avoid locating the medium sand grouting section at the rock interface and prioritize the arrangement in the rock section with a larger elastic modulus.