This article uses a virtual interference inspection method to perform a three-dimensional dynamic simulation of ship retrofitting objects, in order to detect possible interference situations such as insufficient equipment replacement space and obstruction during the retrofitting process in advance. Due to the large number of ship models and numerous surface patches in ship production design, the commonly used interference algorithms have low operational efficiency. In order to improve the efficiency of dynamic interference detection for addition and replacement process, and considering collision accuracy and rigor, a hybrid hierarchical bounding box algorithm based on AABB-OBB is proposed for dynamic collision detection of virtual objects. After verification, this method can quickly perform collision detection in complex virtual environments and generate interference results for production designers to optimize the surrounding ship structure of the replacement equipment, timely and accurately avoiding possible interference problems.