This paper takes an exploration ship as an example to forecast important cabin noise by SEA method and to design acoustic protection for cabins exceeding the standard. Acoustic analysis software VA One was used to establish an acoustic model, and the cabin sound pressure level was predicted when the steel loss factor was taken into account and the influence of internal materials was not considered, so as to determine the main excitation source and transmission path. On this basis, the position of the allowable value of the SOUND pressure level is denoised by predicting the sound pressure level of the cabin after the addition of internal materials. For the air noise, most of the noise is reduced by adding sound insulation board. For structural noise, vibration isolation is mainly adopted, namely, the base of large equipment is changed from rigid support to spring support. After NOISE reduction measures are taken, all the ship's important cabins meet the COMF(NOISE 2) standard of China Classification Society's code for NOISE Comfort. The research results can be used for noise reduction design of the same type of exploration ships and provide a reference for noise reduction design of cabins of other types of ships.