In order to explore the methods for predicting underwater noise in enclosed cabins under the condition of water-air multi-medium, taken the breeding water tank of a 10 0000 t breeding factory ship as the research object, aimed at the analysis frequency band of 300-900 Hz, the Statistical Energy Method (SEA), finite element and boundary element coupling method are used to simulate and test the radiation sound field of the breeding cabin structure, the structural response velocity obtained by SEA is used as the boundary condition of the boundary element model and the noise contribution in different media of the enclosed cabin is analyzed. It is verified through the actual ship testing results that: although there are errors in the numerical simulation, the difference is within the error range; in terms of noise distribution inside the breeding cabin, the predicted and measured values show the same distribution trend. The research method is of certain reference significance for predicting underwater noise in cabins of the same type and similar ships.