Taken the micro underwater vehicle as the research object, the resistance of the vehicle is calculated using Computational Fluid Dynamics (CFD) numerical simulation method. The friction resistance factor Cf is compared with the recommended value of 8th ITTC. A CFD calculation method for the hydrodynamic parameters of an unpowered underwater vehicle with a propeller is proposed. Using this method, based on the basic principles of underwater navigation mechanics, the steady calculation method is used to the numerical simulation test of the oblique flight and steering direct flight, the overall moving grid method is used to the numerical simulation of the rotation constraint model test, the position derivative, rudder derivative and rotation derivative of the vehicle are obtained, and its maneuverability prediction is completed, which lays the foundation for the overall design and control parameter selection of the vehicle.