The Corrosion Resistant Alloy (CRA) clad pipelines under cyclic global buckling with large strain in high temperature high pressure, high sulphur content and strong acid corrosive environment is focused on. A series of fatigue testing of the CRA clad pipeline girth weld under acid corrosive environment are carried out to establish the fatigue knock-down factor of the fatigue endurance S-N curve and the fatigue crack propagation Paris law in acid environment. Based on the parameters obtained from the testing, both S-N fatigue check based on stress and crack propagation fatigue assessment based on Engineering Criticality Assessment (ECA) method are performed to confirm the integrity of the CRA clad pipelines with high temperature high pressure going through cyclic global buckling. Through project specific ECA, the Automatic Ultrosonic Testing (AUT) acceptance criteria for automated ultrasonic testing of girth welds is established for CRA clad pipeline. The design process demonstrated can provide guidance for similar offshore pipeline project.