A nonlinear mechanical model of the riser is established based on the principle of minimum potential energy, and the marine engineering analysis software OrcaFlex is used for numerical simulation. The position of the buoys is dispersed by the control variable method, and single-wave, double-wave and three-wave risers are established. Considering the six degrees of freedom response of FPSO, comparing the vertical motion and overall von Mises stress distribution of the three configurations of the riser, the riser configuration with the best motion isolation effect is determined by comparing the dynamic displacement of the hang-off point. The results show that: the dispersed arrangement of the buoys after considering the response of FPSO is conducive to the smooth transition of the vertical velocity and acceleration of the riser; of the three configurations, the double-wave configuration is of the best effect on optimizing the tension at the hot spot and is of the ability to resist buckling deformation of the material and this configuration is of the best effect on isolating the motion response of FPSO.