Based on the environmental conditions of Bohai area and the pipeline specifications, the influence of clay shear strength Su and sand relative density Dr on the lateral stability of the submarine pipeline is analyzed by AGA software, the engineering investment of increasing the wall-thickness and the weight layer is compared, and the minimum wal-thickness of different specifications meeting the stability is calculated. The calculating results show that: the effect of clay on stability is irregular, but when the shear strength is small, the larger the Su, the worse the stability; the greater the Dr, the worse the stability; the larger the diameter under the condition of clay, the larger the minimum wall-thickness required; Dr has a greater effect on the minimum wall-thickness than Su.