A new idea of semi-submersible medical platform development is proposed by using modular design idea. Numerical simulation of the effect of ward ventilation system is carried out with the help of CFD technology, by comparing the effect of different schemes of ventilation system. And analyze its hydrodynamic response in the complex marine environment, focusing on the influence law of platform hydrodynamic performance on the comfort level of personnel. The conclusions obtained provide references for the development of semi-submersible medical platforms.