In response to the requirements of the rapid and low energy consumption of offshore wind power operation and maintenance ships, the radial basis function interpolation method is used to reconstruct the hull surface. Combined with the calculation tools of computational fluid dynamics and genetic algorithms, with the goal of minimizing wave making resistance, the optimal ship type for wave making resistance is explored, and the optimization of the profile and side-hull spacing of the wind turbine operation and maintenance catamaran is conducted. Taken a wind turbine operation and maintenance catamaran as the research object, the optimal profiles at the speeds of 20 kn and 30 kn are obtained respectively, and the resistance is optimized to certain extent compared with that of the original ship. Based on the method of resistance performance analysis, by selecting different ratios of the distance between the plates, the most suitable distance between the plates is selected, so that the wave-making interference is in favorable conditions. It is obtained that the recommended range of the ratios of the distance between the plates is 2.5~3.5 at the speed of 20 kn. The wave-making resistance of the wind turbine operation and maintenance catamaran is effectively reduced by the proposed optimization method, which provides certain reference for the hull profile design.