A virtual simulation system for ocean engineering is studied. The simulation system is jointly developed by the Application Programming Interface (API) functions of the software Vortex and Vega Prime. The 3D modeling software Creator is applied to create geometrical and geographical models. The physical models with collision detection and dynamics responses are established based on the Vortex software. The overall architecture of the simulation system and the establishment of hardware platform and software platform are completed, and the overall simulation process of ship-cable-body multibody coupling system is described in detail. The operation process of the virtual simulation is demonstrated by a typical ocean engineering case of Pipeline End Termination (PLET) installation. The virtual simulation system plays an important guidance and training role in the offshore construction, production and maintenance.